|
T8849 |
PF-9601N
|
|
MAO
|
|
PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD. |
|
T1308 |
Orphenadrine hydrochloride
|
Mebedrol,Mephenamin |
Sodium Channel
,
NMDAR
,
Norepinephrine
,
iGluR
,
Histamine Receptor
|
|
Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. |
|
T6618 |
Orphenadrine Citrate
|
Flexon,Flexoject,Banflex |
AChR
,
iGluR
|
|
Orphenadrine Citrate (Flexon) is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects. |
|
T2343 |
AS601245
|
|
JNK
|
|
AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties. |
|
T21470L |
Davunetide acetate
|
Davunetide acetate(211439-12-2 Free base) |
Beta Amyloid
,
Microtubule Associated
|
|
Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS. Davunetide acetate is a microtubule-stabilizing peptide and inhibits Aβ aggregation and Aβ-induced neurotoxicit... |
|
T21268L |
Semax acetate(80714-61-0 free base)
|
|
Others
|
|
Semax acetate is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties. |
|
T67908 |
ThioLox
|
|
Lipoxygenase
|
|
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with IC50 value of 12 μM. ThioLox shows anti-inflammatory and neuroprotective properties. It has anti-inflammatory and neuroprotective effects, and has a st... |
|
TP1570L |
Cortistatin-14 acetate
|
Cortistatin-14 acetate(186901-48-4 Free base) |
Somatostatin
|
|
Cortistatin-14 acetate, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 acetate shows anticonvulsive, neuroprotective... |
|
TP1188L |
Cortistatin 14, human, rat acetate
|
|
Somatostatin
|
|
Cortistatin 14, human, rat acetate is a neuropeptide having structural similarity to somatostatin-14 and shows anticonvulsive, neuroprotective effects and remarkable anti-inflammatory properties. Cortistatin 14, human, r... |
|
T22513 |
4-PPBP maleate
|
|
Sigma receptor
,
NMDAR
|
|
4-PPBP maleate is a potent σ1 receptor (ligand) agonist. 4-PPBP maleate can be considered a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression. 4-PPBP maleate has neu... |
|
T50003 |
Debrisoquin hydriodide
|
1,2,3,4-tetrahydroisoquinoline-2-carboximidamide hydroiodide |
Others
|
|
Debrisoquin hydriodide (1,2,3,4-tetrahydroisoquinoline-2-carboximidamide hydroiodide) has antioxidant, anti-inflammatory and neuroprotective properties. It has also been found to modulate the activity of certain neurotra... |
|
T77332 |
TV 3279
|
|
BCL
,
PKC
|
|
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apopto... |
|
T7826 |
6-Chloropurine riboside
|
|
Others
|
|
6-Chloropurine riboside (6-CPR) is a purine nucleoside analog that has been found to have a wide range of biological activities. It inhibits the growth of tumor cells and induces apoptosis. It has also been shown to have... |
|
T21687 |
Conoidin A
|
|
Parasite
|
|
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation ... |
|
T23265 |
RS 67333 hydrochloride
|
RS 67333 (hydrochloride),RS 67333 HCl |
5-HT Receptor
|
|
RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, inclu... |
|
T31469 |
Dihydroergostin
|
DE145,DE-145,DE 145 |
|
|
Dihydroergostin is a ergot alkaloid that exhibits potential neuroprotective properties. |
|
T35056 |
Vindeburnol
|
RU 24722,RU24722,RU-24722 |
|
|
Vindeburnol is a cerebral vasodilator vincamine analog that bears neuroprotective properties. |
|
T21268 |
Semax
|
|
|
|
Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties. |
|
T14504 |
BAY 38-7271
|
|
Cannabinoid Receptor
|
|
BAY 38-7271 has strong neuroprotective properties.[1] BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist. With Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 recept... |
|
T12816 |
(S)-Trolox
|
|
Others
|
|
(S)-Trolox, an analogue of vitamin E, substitutes the phytyl chain with a carboxyl group. This compound serves as a model substance in structural studies and as a standard for assessing antioxidant activity. Moreover, (S... |
|
T61131 |
MAO-B-IN-11
|
|
|
|
MAO-B-IN-11, also known as Compound 8c, is a highly potent inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 1.3 μM. Additionally, MAO-B-IN-11 exhibits neuroprotective properties [1]. |
|
T39120 |
Fluoroethylnormemantine
|
|
|
|
Fluoroethylnormemantine, a derivative of Memantine, acts as an N-methyl-D-aspartate (NMDA) receptor antagonist. It can function as a positron emission tomography (PET) tracer, known as [18F]-fluoroethylnormemantine. This... |
|
T81409 |
Pregnanolone sulfate (pyridinium)
|
|
iGluR
|
|
Pregnanolone sulfate pyridinium, an endogenous neurosteroid, inhibits NMDA receptors and exhibits neuroprotective properties [1]. |
|
T70064 |
PDE1-IN-1
|
|
|
|
PDE1-IN-1can enhance levels of the second messengers cAMP/cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and neuroprotective molecules. These neuronal plasticity enhancement pr... |
|
T40245 |
Miroestrol
|
|
|
|
Miroestrol is a potent phytoestrogen compound with multifaceted biological effects. It induces a mammogenic effect and demonstrates neuroprotective properties, along with the ability to prevent bone loss in ovariectomize... |
|
T69595 |
Ispronicline hemigalactarate
|
|
|
|
Ispronicline, also known as AZD3480; TC 1734; TC-0173, and RJR 1734, is a alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Ispronicline is potenti... |
|
T80634 |
MAO-B-IN-19
|
|
Monoamine Oxidase
|
|
MAO-B-IN-19, a selective MAO-B inhibitor, exhibits neuroprotective and anti-inflammatory properties and demonstrates an IC50 value of 0.67 μM [1]. |
|
T38601 |
GYKI-47261 dihydrochloride
|
|
|
|
GYKI-47261 dihydrochloride is a selective AMPA receptor antagonist, administered orally, and exhibits competitive activity with an IC 50 of 2.5 μM. It displays a wide range of anticonvulsive effects and demonstrates neur... |
|
T39119 |
Fluoroethylnormemantine hydrochloride
|
|
|
|
Fluoroethylnormemantine hydrochloride, a Memantine derivative, functions as an antagonist for the N-methyl-D-aspartate (NMDA) receptor. It can also serve as a positron emission tomography (PET) tracer, specifically as [1... |
|
T78592 |
Diapocynin
|
Dehydrodiacetovanillone |
|
|
Diapocynin (Dehydrodiacetovanillone), a dimer of Apocynin, acts as an orally administered inhibitor of NADPH oxidase. It exhibits anti-inflammatory, neuroprotective, and antioxidant properties [1]. |
|
T61660 |
FGFR-IN-3
|
|
|
|
FGFR-IN-3 (compound 6) is a highly potent and orally active modulator of FGFR (fibroblast growth factor receptor). It has the ability to penetrate the blood-brain barrier (BBB). Additionally, FGFR-IN-3 exhibits significa... |
|
T13734 |
ILS-920
|
|
Others
|
|
|
|
T61528 |
FGFR-IN-7
|
|
|
|
FGFR-IN-7 (compound 17) is an orally active, potent FGFR modulator with the ability to penetrate the blood-brain barrier. It exhibits neuroprotective properties, enhancing brain exposure and decreasing the likelihood of ... |
|
T74854 |
GluN2B-NMDAR antagonist-1
|
|
|
|
GluN2B-NMDAR Antagonist-1, an orally active compound, functions as a GluN2B-NMDAR antagonist with neuroprotective properties. It is applicable in the research of ischemic injury [1]. |
|
T81635 |
Nurr1 agonist 5
|
|
|
|
Compound 5o, a Nurr1 agonist, exhibits neuroprotective properties as a transcription factor Nurr1 agonist, possessing a dissociation constant (Kd) of 0.5 μM and a half-maximal effective concentration (EC50) of 3 μM [1]. |
|
T82292 |
Gluten Exorphin A5
|
|
|
|
Gluten Exorphin A5, a wheat gluten-derived peptide, exhibits neuroprotective properties and influences both the central and peripheral nervous systems [1]. |
|
T37096 |
Sepimostat dimethanesulfonate
|
|
|
|
Sepimostat dimethanesulfonate (FUT-187), a chemical compound, demonstrates neuroprotective properties by antagonizing NR2B N-methyl-D-aspartate receptors at the NR2B subunit's Ifenprodil-binding site. This compound effec... |
|
T61522 |
Nrf2/HO-1 activator 2
|
|
|
|
Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway t... |
|
T40701 |
Ezeprogind
|
AZP-2006 |
|
|
Ezeprogind (AZP-2006) is an orally active neurotrophic inducer that effectively addresses the underlying factors contributing to neurodegeneration, with a broad scope extending beyond the conventional targets like Abeta ... |
|
T73671 |
7β-Hydroxy-epi-androsterone
|
|
|
|
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) is an endogenous androgenic derivative of dehydroepiandrosterone that possesses the ability to bind to ERβ, offering both anti-inflammatory and neuroprotective properties [1]... |
|
T39513 |
Ladostigil hemitartrate
|
TV-3326 hemitartrate,Ladostigil hemitartrate |
|
|
Ladostigil hemitartrate (TV-3326) is a compound that acts as a dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO). It has IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. In addition, Lado... |
|
T39823 |
Apelin-12
|
|
|
|
Apelin-12 is a highly potent C-terminal fragment of a polypeptide that exhibits a strong affinity towards the orphan receptor APJ. It plays a role in maintaining body fluid balance and regulating feeding control in the c... |
|
T76034 |
Cortistatin-14 TFA
|
|
|
|
Cortistatin-14 (TFA), a neuropeptide resembling somatostatin-14 in structure, operates through interaction with somatostatin receptors (sst1-sst5). This compound exhibits anticonvulsive and neuroprotective effects alongs... |
|
T73507 |
NS1219
|
(R)-SPD502 |
|
|
NS1219 ((R)-SPD502), an isomer of NS1209, functions as a selective antagonist for AMPA receptors, exhibiting neuroprotective properties. This compound is utilized in research related to stroke, neuropathic pain, and epil... |
|
T77998 |
(Arg)9 acetate
|
Peptide R9 acetate,Nona-L-arginine acetate |
|
|
Nona-L-arginine (Arg)9 acetate, a cell-penetrating peptide (CPP) consisting of 9 arginine residues, displays neuroprotective properties, with an IC50 of 0.78 μM in the glutamic acid model [1] [2]. |
|
T78023 |
MR 409
|
|
|
|
MR 409, a selective growth hormone-releasing hormone (GHRH) agonist, exhibits notable neuroprotective properties by augmenting endogenous neurogenesis in cerebral ischemic mice and demonstrates the ability to inhibit in ... |
|
T73214 |
RX 801077
|
2 BFI free base |
|
|
RX 801077 (2 BFI free base), a selective imidazoline I2 receptor (I2R) agonist, exhibits a K i value of 70.1 nM, demonstrating anti-inflammatory and neuroprotective properties. This compound holds research potential for ... |
|
T78907 |
MAO-B-IN-22
|
|
Monoamine Oxidase
|
|
MAO-B-IN-22 (compound 6h) represents a powerful MAO-B inhibitor, boasting an IC50 value of 0.014 μM, and exhibits high antioxidant activity alongside effective metal-chelating properties. It also demonstrates adequate BB... |
|
T62516 |
SV5
|
|
|
|
SV5 is a potent anti-Alzheimer agent. sv5 significantly protects SHSY-5Y cells from Aβ1-42-induced death. sv5 is highly stable and has optimal pharmacological properties in human plasma. sv5 has appropriate antioxidant a... |
|
T78067 |
Stobadine
|
(-)-Stobadine |
Reactive Oxygen Species
|
|
Stobadine, a potent antioxidant, safeguards endoplasmic reticulum (ER) membrane fluidity against free radical-induced changes. It shows promise in the development of cardio- and neuroprotective agents owing to its mechan... |
